Xandrox 15% Solution

Q. What is Xandrox 15% Solution®? 
A. Xandrox15% Solution® is an exclusive Regrowth medication for the treatment of alopecia androgenetica, containing 15% minoxidil and 5% azelaic acid by weight.  Xandrox15% Solution® is available in 125mL bottles.  Each mL of Xandrox 15% Solution® contains 150mg of minoxidil and 50mg of azelaic acid.  
 
Q. Why is Xandrox 15% Solution® considered to be a breakthrough product? 
A. This is the first minoxidil solution in which the base liquid contains a concentration of minoxidil considerably greater than 5%.  Minoxidil had been considered to be soluble in alcohol-based solutions only to the extent of slightly less than 5%.  To make a stable, high concentration minoxidil solution required years of experimentation, research and development.  The result has been rewarding.  Xandrox 15% Solution® is a clear, colorless to light amber colored, solution, containing 15% minoxidil and 5% azelaic acid with a proven efficacy in the treatment of MPB.

Q. Regrowth already offers a Xandrox 12.5% Lotion®.  What’s the advantage of a Xandrox 15% Solution®? 
A. (1) Convenience. Many patients find a solution is more convenient to apply to the scalp than a lotion.  The tip of the dropper can be placed directly onto the scalp with a minimal amount of solution wasted on coating the hair shafts.  Whereas a lotion can be conveniently applied to areas of the scalp with little hair or miniaturized hair, the solution is easily applied anywhere on the scalp, including larger areas of thinning hair. 

(2) Stability.  Whereas the lotion has a tendency to separate at temperatures above 100 oF (38 oC), the Xandrox 15% Solution® is stable at subfreezing temperatures to temperatures above 200 oF (93 oC). There are no problems in regards to keeping the Xandrox 15% Solution® indoors, outdoors or even in your car.

(3) Efficacy.  The hair promoting effects of topical minoxidil are dose related.  The additional 2.5% minoxidil concentration combined with the greater absorption of the alcohol based Xandrox 15 Solution® is more effective in recruiting miniaturized hair follicles to mature again and produce a terminal hair shaft.

(4) Cost.  It actually costs less in labor to compound Xandrox 15% Solution®, than to compound 12.5% Xandrox Lotion®.  We pass the savings on to the patient.

Q. Is the effectiveness of Xandrox 15% Solution® superior to Xandrox 12.5% Lotion®? 
A. It can be.  It is well established that the effectiveness of topical minoxidil in treating MPB is dose related.  In our test group, patients grew more hair using Xandrox 15% Solution® in areas where they had been using Xandrox 12.5% Lotion®.  There appears to be a threshold level of stimulation with minoxidil to which follicles can be recruited to grow terminal hair again.  This threshold level will vary considerably among patients depending primarily on their genetic predisposition to MPB and the length of time affected hair follicles have been miniaturized.
 
Q. Are there any special precautions relating to the 125 mL bottles of Xandrox15 Solution®? 
A. Because of the volatility of the ethyl alcohol, the bottle should be tightly capped when the solution is not being used.  The solution is extremely stable within a wide range of temperatures and has been tested to be unaffected in the range of 10° to 200° Fahrenheit (-12° to 93° Centigrade) for short exposures.  Xandrox 15 Solution® is best kept at room temperatures.   

Q. Are there other advantages to using 5% Xandrox® solutions as compared to Rogaine®/Regaine Extra Strength® and finasteride? 
A. Yes. There are many advantages. (1) Cost: A one month supply of 5% Xandrox® costs considerably less than a one month supply of Rogaine®/Regaine Extra Strength® (or its generic version) plus a one month supply of finasteride. (2) Convenience: instead of applying minoxidil twice/day topically and taking finasteride orally, 1 mL of Xandrox® is applied topically twice/day. (3) Side effects: Oral finasteride can cause sexual dysfunction in a significant percentage of patients.  Xandrox® solutions have no side effects. (4) Safety: The long-term effects of finasteride are not yet known. Minoxidil has been in use for many decades and azelaic acid has been ingested as long as mankind has been eating whole grains. It has even been proven safe when used systemically and intravenously.